{"id":80933,"date":"2025-09-12T11:32:15","date_gmt":"2025-09-12T02:32:15","guid":{"rendered":"http:\/\/ic-clinic-ueno.com\/rybelsus\/"},"modified":"2026-07-06T19:18:46","modified_gmt":"2026-07-06T10:18:46","slug":"rybelsus","status":"publish","type":"page","link":"https:\/\/ic-clinic-ueno.com\/en\/treatment\/rybelsus\/","title":{"rendered":"Medical Weight Loss with Rybelsus (Semaglutide)"},"content":{"rendered":"

Rybelsus is an oral medication containing semaglutide as its active ingredient<\/span>. Semaglutide is a GLP-1 receptor agonist originally developed as a treatment for type 2 diabetes, but its weight reduction properties have also attracted attention in the field of medical weight management<\/span>.<\/p>\n\n

While conventional GLP-1 receptor agonists were available only as injections, Rybelsus was approved in the United States in 2019 as the world\u2019s first oral GLP-1 receptor agonist, and received approval in Japan in 2021 as a treatment for type 2 diabetes<\/span>. \ud83d\udc89 It is a treatment option that is easier to start for those who are uncomfortable with injections<\/span>.<\/p>\n\n\n

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\ud83d\udcc5 Book Online Now<\/a><\/div>\n\n<\/div>\n\n\n
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\ud83d\udd2c Mechanism of Action<\/h2>\n\n

Semaglutide, the active ingredient in Rybelsus, works in a manner similar to GLP-1, a hormone naturally secreted by the body<\/span>. GLP-1 is a hormone released from the small intestine in response to food intake, and plays an important role in regulating blood glucose levels<\/span>.<\/p>\n\n

\u2728 Key Actions<\/h3>\n\n

1. \ud83c\udf7d\ufe0f Appetite Suppression<\/span>
It acts on the satiety centre in the hypothalamus of the brain to suppress appetite<\/span>. This leads to a natural reduction in food intake, allowing caloric consumption to decrease without strict dietary restriction<\/span>.<\/p>\n\n

2. \u23f0 Delayed Gastric Emptying<\/span>
By slowing the movement of food from the stomach to the intestines, a feeling of fullness is maintained for a longer period<\/span>. This may help reduce snacking and overeating<\/span>.<\/p>\n\n

3. \ud83d\udcca Stimulation of Insulin Secretion & Suppression of Glucagon Secretion<\/span>
It promotes insulin secretion in response to blood glucose levels while simultaneously suppressing glucagon, which raises blood glucose. This contributes to stabilisation of blood glucose levels<\/span>.<\/p>\n\n

4. \ud83d\udd25 Promotion of Fat Breakdown<\/span>
It has the effect of promoting fat breakdown within the body and increasing energy expenditure<\/span>.<\/p>\n\n

\ud83d\udcaa Potential Effects<\/h2>\n\n

\u2696\ufe0f Weight Reduction<\/h3>\n\n

In clinical trials, significant weight reduction has been observed in patients taking Rybelsus<\/span>. Results may vary among individuals, but combining Rybelsus with appropriate dietary therapy and exercise may support more effective weight management<\/span>.<\/p>\n\n

\ud83d\udcc8 Blood Glucose Stabilisation<\/h3>\n\n

By suppressing postprandial blood glucose spikes and reducing fluctuations in blood glucose levels<\/span>, it may contribute to the prevention and management of diabetes. Stable blood glucose levels may also make it easier to manage food cravings<\/span>.<\/p>\n\n

\ud83e\udec0 Visceral Fat Reduction<\/h3>\n\n

Along with overall weight reduction, visceral fat reduction in particular<\/span> may be expected. A decrease in visceral fat may contribute to improvement of metabolic syndrome and prevention of lifestyle-related diseases<\/span>.<\/p>\n\n

\ud83c\udf74 Improvement of Eating Behaviour<\/h3>\n\n

By normalising appetite, dietary control that was previously difficult may become easier to manage<\/span>. It may become possible to achieve satisfaction with appropriate portion sizes and to reduce binge eating and drinking<\/span>.<\/p>\n\n\n

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\nKota Takakuwa<\/span>\nPhysician & Treatment Director<\/span>\n<\/div>\n

The greatest feature of Rybelsus is that it allows patients to begin treatment without the barrier of injections. Many patients tell us that \u201cthe urge to eat naturally settled down.\u201d That said, rather than relying solely on the medication, building appropriate dietary and exercise habits alongside treatment is expected to support more sustained results.<\/p>\n<\/div>\n\n\n

\ud83d\udccb Dosage and Administration<\/h2>\n\n

\ud83d\udcc5 Initial Dosing and Dose Escalation Schedule<\/h3>\n\n

Rybelsus requires a gradual dose escalation<\/span>. This is to minimise side effects and allow the body to adjust to the medication<\/span>.<\/p>\n\n